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The prospective study that followed 4,007 individuals with or without cardiovascular disease for a three-year period found baseline concentrations of circulating TMAO to be positively correlated with incidence of death, nonfatal myocardial infarction, and stroke described as major adverse cardiac events (MACE) (23)

The copper-complex form is the biologically active species in most published research contexts the free tripeptide acquires copper from endogenous sources in physiological conditions, but in most research applications the pre-formed complex is what is used

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In: OffermannsSRosenthalW, editors