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Additional information Peer review information Nature Communications thanks Stevan Hubbard, Kenneth Siddle and the other, anonymous, reviewer for their contribution to the peer review of this work

No changes in blood pressure, body weight, food intake, or trends in erectile activity were observed during the MAD trial (63)

Despite the established significance of postprandial gutbrain signaling in energy and glucose homeostasis, recent work highlights the physiological and neural complexity of this negative feedback and questions this gut peptide-mediated vagal signaling

10.3233/JAD-201274 317 ZhangH.WangY.LyuD.LiY.LiW.WangQ.et al (2021b)

Reduced Appetite: These medications enhance satiety, leading to reduced food intake and better adherence to dietary changes