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But, how long and how often can change based on your needs and the issue youre tackling

It should not be frozen

About 4 - 6 weeks for most

Optionally, a controlled-release formulation includes otoprotective agents, such as antioxidants, alpha lipoic acid, calcium, fosfomycin or iron chelators, to counteract potential ototoxic effects that may arise from the use of specific therapeutic agents or excipients, diluents, or carriers

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