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In vehicle-treated rats, fentanyl elicited (1) an increase in TFL, (2) decreases in pH, pO 2 and sO 2 and increases in pCO 2 (all indicative of ventilatory depression), (3) an increase in Alveolar-arterial gradient (indicative of a mismatch in ventilation-perfusion in the lungs), and (4) changes in ventilatory parameters such as a reduction in tidal volume, that were indicative of pronounced ventilatory depression
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [(11)C]PBR28
Most patients experience significant weight loss despite early nausea, which typically resolves within four to six weeks
Dehydration commonly produces symptoms including fatigue, headache, dizziness, muscle weakness, and general malaise, which patients may interpret as flu-like
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