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In addition to their significant A1C-lowering effects, the landmark clinical trials for these respective agents found substantial appetite suppression, less feeling of "reward" after eating, and subsequent weight loss

A key structural feature is the incorporation of an alpha-aminoisobutyric acid (Aib) at several positions to enhance proteolytic stability against dipeptidyl peptidase-4 (DPP-4)

SIRT1/HSF1/HSP Pathway is Essential for Exenatide-Alleviated, Lipid-Induced Hepatic Endoplasmic Reticulum Stress

That clinical evidence applies to FDA-approved versions of these active ingredients

The amylin-based mechanism may contribute to this selectivity