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Forelimb grip strength was determined by allowing animals to clasp a suspended wire and the time to release was recorded in females [Young ( n = 8), Old Con ( n = 12), and Old mAb ( n = 15)] and males [Young ( n = 8), Old Con ( n = 10), and Old mAb ( n = 9)]
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Additionally, the DEF/YxP motif (residues 134-138) at the C-terminal end of Syn is critical for anchoring to the histone H2a-H2b dimer
The preparation of S1-Gem, S-PTX, C-PTX, S1-DOX, S2-DOX, Se1-DOX, Se2-DOX, C-DOX, and Se-NBL followed synthetic routes analogous to S2-SN38, with S1-Gem exhibiting a diminished yield of 8% and other compounds demonstrating yields spanning 1050%
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