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For instance, TEPP-46 and microbial metabolite-based therapies (e.g., butyrate, itaconate) exhibit robust efficacy in animal models but have yet to be systematically evaluated in human autoimmune populations

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It has been postulated that both of the chemicals influence respiratory reactions and energy production by regulating acetyl-CoA concentration (30)

M.TerronesO.BasanezG.et al (2008)

Slight stomach discomfort if taken without food