The rationale, from a pharmacological standpoint, is that retatrutide's action on GLP-1, GIP, and glucagon receptors drives significant caloric deficit and improved insulin sensitivity, whilst sermorelin's stimulation of endogenous growth hormone release may support lipolysis and muscle protein synthesis
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1 However, many patients stop taking GLP-1s within the first year of treatment due to side effects, cost, insurance barriers, or clinical decisions
Additionally, while some studies raise concerns about GLP-1s increasing depression, anxiety, and suicidal thoughts, other studies point in the opposite direction, noting a decrease in depressive symptoms, improved cognitive function, and an increase in feelings of self-mastery
In contrast, a number of patients with lipodystrophy show hypertension in the leptin-deficient state [263, 264]
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